Esgic Plus is a barbiturate sedative (butalbital) mixed with a non-aspirin pain medication (acetaminophen) and caffeine. This non-narcotic pain medication and relaxant is often prescribed for tension headaches caused by contractions of the muscles in the neck and shoulder area, and migraines. Acetaminophen is a pain reliever and fever reducer. Butalbital is in a class of drugs called barbiturates that slow down your central nervous system (brain and nerve impulses) causing relaxation. Caffeine is believed to constrict dilated blood vessels that may contribute to tension headaches.

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The following information is intended to supplement, not substitute for, the expertise and judgment of your physician, pharmacist or other healthcare professional. It should not be construed to indicate that use of the drug is safe, appropriate, or effective for you. Please consult your healthcare professional before using this or any other prescription or non-prescription medication.


Esgic Plus Directions

To prevent upset stomach, take Esgic with food or milk. Pain medications work best in preventing pain before it occurs. Once the pain becomes intense, Esgic is not as effective in relieving it. Take Esgic as prescribed. Do not increase your dose or take Esgic more frequently without your doctor's approval.


Esgic Plus Side Effects

If you experience any of the following serious side effects, stop taking acetaminophen / butalbital / caffeine and seek emergency medical attention: an allergic reaction (difficulty breathing; closing of your throat; swelling of your lips, tongue, or face; or hives); slow, weak breathing; liver damage.


Esgic Plus Precautions

Use caution when driving, operating machinery, or performing other hazardous activities. Butalbital will cause drowsiness or dizziness. If you experience drowsiness or dizziness, avoid these activities. Avoid sleeping pills, antihistamines, sedatives, and tranquilizers except under the supervision of your doctor.


Drug Interactions with Esgic Plus

Do not take acetaminophen / butalbital / caffeine if you have taken a monoamine oxidase inhibitor


Esgic Plus Overdose

Seek emergency medical attention. Symptoms of an acetaminophen / butalbital / caffeine overdose include insomnia, restlessness, tremor, nausea, vomiting, diarrhea, abdominal pain, sweating, seizures, drowsiness, decreased breathing, dizziness or fainting, confusion, an irregular heartbeat, and coma.